A Algorithms and Computational Biology Lab

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Oligonucleotide fingerprinting of ribosomal RNA genes (OFRG) is a method that permits the identification of arrayed ribosomal RNA genes (rDNA) through a series of hybridizaition experiments using small DNA probes. It provides a cost effective means to extensively analyze microbial communities and should have application in medicine, biotechnology and ecosystem studies. This project is funded by NSF DBI. PRImer Selector (PRISE) is an interactive software package for PCR primer design. PRISE enables the design of sequence-specific / sequence-selective PCR primers. One important feature of PRISE is that it automates the task of placing primer-template mismatches at the 3' end of the primers - a property that is crucial for sequence selectivity / specificity.


OligoSpawn is an efficient software for selecting two types of oligos, namely unique and popular oligos, from large unigene databases. MSOAR is a high-throughput system for ortholog assignment on a genome scale.


Two Sample Logo is a web-based application that calculates and visualizes differences between two sets of aligned samples of amino acids or nucleotides. FLowgram Alignment Tool (FLAT) is a method for probabilistic matching of small RNA flowgrams against the reference genome.


LRTag is an efficient software tool for selecting a minimum set of TagSNPs across multiple populations via the linkage disequilibrium criteria. MSTmap is a genetic mapping tool which constructs the initial genetic map from the minimum spanning tree (MST) of a graph. It is able to detect genotyping errors and can handle various mapping populations including DH, Hap, BC, and RIL.


MergeMap is software tool for merging individual genetic linkage maps into a consensus map. When there are conflicts among the individual maps, MergeMap is able to produce a graph which highlights the possible problematic marker occurrences.